BARDA

Seres Therapeutics’ oral microbiome treatment for C. difficile infections (CDI) proved superior to placebo in reducing CDI recurrence, according to Phase 3 data published last week in the New England Journal of Medicine. Touting the “first-ever positive pivotal clinical results for a targeted microbiome drug,” the Massachusetts-based company said in a press release it would finalize its U.S. FDA Biologics License Application for SER-109 in mid-2022.

The treatment boasts FDA…

Moderna’s mRNA-1010 quadrivalent seasonal influenza vaccine candidate boosted antibody titers against all four strains in both younger and older adults, according to interim Phase 1 data the Massachusetts-based biotech shared last week. The company also revealed that it is developing two “beyond quadrivalent” seasonal flu vaccine candidates—mRNA-1011 and mRNA-1012—that it believes will “expand strain coverage and enhance tools available to public health authorities when selecting antigens,”…

The U.S. Biomedical Advanced Research and Development Authority (BARDA) has made two recent Sudan ebolavirus and Marburg virus vaccine awards.

Firstly, the International AIDS Vaccine Initiative (IAVI) said Wednesday that BARDA has given it up to $126 million to help develop its two recombinant vesicular stomatitis virus (rVSV)-vectored candidates.

Meanwhile, Sabin Vaccine Institute announced last week that BARDA has released a third tranche of $34.5 million in funding to allow…

BD announced last week that it has completed new needle and syringe manufacturing lines in its Holdrege, Nebraska facility more quickly than initially planned in order to meet surging U.S. demand spurred by the Covid-19 pandemic.

The $70 million project included $42 million in funding from the U.S. Biomedical Advanced Research and Development Authority, the press release noted.

Seqirus announced on Tuesday that the U.S. Biomedical Advanced Research and Development Authority has picked the CSL subsidiary to develop two influenza A(H2Nx) vaccine candidates through Phase 1.

The $35 million deal will evaluate one cell-based and adjuvanted candidate and one self-amplifying mRNA (sa-mRNA) shot, the New Jersey-based company said in a press release.

A therapy for the prevention of recurrent C. difficile infection (CDI) in high-risk patients has met the primary endpoint in a Phase 2 trial, Vedanta Biosciences announced Tuesday. The Massachusetts-based company’s VE303, an orally administered live biotherapeutic, yielded a 31.7% absolute risk reduction in rate of recurrence versus placebo, according to a press release.

Based on the Phase 2 data, the U.S. Biomedical Advanced Research and Development Authority (BARDA) exercised an…

Basilea Pharmaceutica announced Monday that the U.S. Biomedical Advanced Research and Development Authority has increased its total investment in the Swiss company’s ceftobiprole antibiotic candidate to $134.2 million.

The new tranche of $4.3 million will support a Phase 3 trial to evaluate the intravenous drug as an S. aureus bacteremia treatment, the press release said.

The Basel-based company won funding from CARB-X in May to develop a novel class of antibiotics against drug-…

The U.S. Biomedical Advanced Research and Development Authority will add more than $12 million to an existing contract with Massachusetts-based Public Health Vaccines LLC to advance its Marburg candidate into clinical trials, the company announced Wednesday.

The deal extends an original $10 million award for the recombinant vesicular stomatitis virus (rVSV)-based candidate, according to the press release. The contract also includes an option for the parallel development of a Sudan…

Boston University-led nonprofit CARB-X announced Tuesday that it will give Arizona-based Accelerate Diagnostics $578,000 (plus up to $2.1 million in milestones) to develop a rapid optical imaging diagnostic for sepsis and serious antibiotic-resistant bacterial infections.

In other antimicrobial resistance news, Boston’s Selux Diagnostics announced Tuesday an additional $14.6 million award from the U.S. Biomedical Advanced Research and Development Authority (BARDA) to develop a rapid…

The U.S. Biomedical Advanced Research and Development Authority (BARDA) announced Monday that it has selected the Global Health Investment Corporation (GHIC)—parent of the Global Health Investment Fund and an investor in Adjuvant Capital—as its venture partner.

BARDA has committed a minimum of $50 million over five years to GHIC, with potential for up to $500 million over 10 years through its BARDA Ventures initiative, according to its press release. The goal: to accelerate development…